No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
4442 |
6. Filter based on genotype QC (FinnGen only) |
4271 |
Control definitions (FinnGen only)
Control exclude
ASTHMA_COMORB
Extra metadata
First used in FinnGen datafreeze
DF2
Smoking
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 34751 | 16898 | 17703 |
| Only index persons | 33418 | 16544 | 16874 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.49 | 0.48 | 0.49 |
| Only index persons | 0.63 | 0.61 | 0.64 |
| Median age at first event (years) | |||
| Whole population | 53.76 | 49.18 | 58.21 |
| Only index persons | 53.42 | 48.77 | 57.98 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4271 | 2216 | 2055 |
| Unadjusted period prevalence (%) | 0.95 | 0.87 | 1.03 |
| Median age at first event (years) | 55.10 | 51.33 | 59.16 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint SMOKING and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| SMOKING | 4.248 [3.64, 4.95] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.223 |
During the follow-up period (1.1.1998 — 31.12.2019), 1644 out of 13938 females with SMOKING died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| SMOKING | 3.988 [3.49, 4.56] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 3487 out of 14174 males with SMOKING died.
Mortality risk
Mortality risk for people of age
years, who have SMOKING.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.38% | 0.535% |
| 5 | 2.336% | 3.353% |
| 10 | 5.908% | 9.596% |
| 15 | 11.395% | 18.337% |
| 20 | 19.993% | 29.903% |
Relationships between endpoints
↥Index endpoint: SMOKING – Smoking
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data