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Cluster headache, wide

Endpoint Browser PheWeb

G6_CLUSTHEADACHE_WIDE

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G44.0
  • Hospital discharge: ICD-9 — 3468X
  • Hospital discharge: ICD-8 — 34601
  • Cause of death: ICD-10 — G44.0
  • Cause of death: ICD-9 — 3468X
  • Cause of death: ICD-8 — 34601

2 out of 7 registries used, show all original rules.

1408

4. Check minimum number of events

None

1408

5. Include endpoints

1408

6. Filter based on genotype QC (FinnGen only)

1355

Control definitions (FinnGen only)

Control exclude G6_EPIPAROX

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF6

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 9585 4244 5266
Only index persons 9107 4097 5010
Unadjusted period prevalence (%)
Whole population 0.14 0.12 0.15
Only index persons 0.17 0.15 0.19
Median age at first event (years)
Whole population 41.39 42.50 40.51
Only index persons 40.96 42.12 40.01

-FinnGen-

Key figures

All Female Male
Number of individuals 1355 786 569
Unadjusted period prevalence (%) 0.30 0.31 0.29
Median age at first event (years) 45.01 42.99 47.80

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint G6_CLUSTHEADACHE_WIDE and mortality.

Females

Parameter HR [95% CI] p-value
G6_CLUSTHEADACHE_WIDE 1.026 [0.85, 1.24] 0.79
Birth year 0.992 [0.98, 1.0] 0.085

During the follow-up period (1.1.1998 — 31.12.2019), 169 out of 3215 females with G6_CLUSTHEADACHE_WIDE died.

Males

Parameter HR [95% CI] p-value
G6_CLUSTHEADACHE_WIDE 1.249 [1.08, 1.44] 0.002
Birth year 0.988 [0.98, 1.0] 0.019

During the follow-up period (1.1.1998 — 31.12.2019), 339 out of 4187 males with G6_CLUSTHEADACHE_WIDE died.

Mortality risk

Mortality risk for people of age

years, who have G6_CLUSTHEADACHE_WIDE.

N-year risk Females Males
1 0.116% 0.231%
5 0.623% 1.271%
10 1.415% 3.425%
15 2.806% 6.856%
20 4.755% 11.961%

Relationships between endpoints

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Index endpoint: G6_CLUSTHEADACHE_WIDE – Cluster headache, wide

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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