No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
2467 |
4. Check minimum number of eventsNone |
2467 |
5. Include endpoints |
2719 |
6. Filter based on genotype QC (FinnGen only) |
2642 |
Control definitions (FinnGen only)
Control exclude
G6_OTHNEU
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G90-G99
Name in latin
Hydrocephalia
Similar endpoints
↥List of similar endpoints to
Hydrocephalus
based on the number of shared cases.
Similar with more cases:
- Other neurological diseases
- Neurological diseases
- Neurological diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 22296 | 10875 | 11155 |
| Only index persons | 16604 | 8404 | 8200 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.31 | 0.31 | 0.31 |
| Only index persons | 0.31 | 0.31 | 0.31 |
| Median age at first event (years) | |||
| Whole population | 62.99 | 64.83 | 61.03 |
| Only index persons | 62.42 | 64.39 | 60.41 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2642 | 1328 | 1314 |
| Unadjusted period prevalence (%) | 0.59 | 0.52 | 0.66 |
| Median age at first event (years) | 67.97 | 67.01 | 68.94 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint G6_HYDROCEPH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HYDROCEPH | 2.789 [2.54, 3.07] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.613 |
During the follow-up period (1.1.1998 — 31.12.2019), 2969 out of 7243 females with G6_HYDROCEPH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HYDROCEPH | 2.805 [2.5, 3.15] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 3085 out of 7216 males with G6_HYDROCEPH died.
Mortality risk
Mortality risk for people of age
years, who have G6_HYDROCEPH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.225% | 0.549% |
| 5 | 1.497% | 3.18% |
| 10 | 4.065% | 7.872% |
| 15 | 8.242% | 15.241% |
| 20 | 14.097% | 25.051% |
Relationships between endpoints
↥Index endpoint: G6_HYDROCEPH – Hydrocephalus
GWS hits: 7
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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