age-related macular degeneration: Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
11413 |
6. Filter based on genotype QC (FinnGen only) |
11023 |
Control definitions (FinnGen only)
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF3
Similar endpoints
↥List of similar endpoints to
Age-related macular degeneration (whether dry or wet)
based on the number of shared cases.
Similar with more cases:
- Degeneration of macula and posterior pole
- Other retinal disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 108178 | 68711 | 38987 |
| Only index persons | 97698 | 62764 | 34934 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.64 | 1.97 | 1.09 |
| Only index persons | 1.96 | 2.31 | 1.33 |
| Median age at first event (years) | |||
| Whole population | 79.03 | 79.89 | 77.52 |
| Only index persons | 78.80 | 79.71 | 77.17 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 11023 | 5776 | 5247 |
| Unadjusted period prevalence (%) | 2.44 | 2.27 | 2.64 |
| Median age at first event (years) | 76.19 | 76.42 | 75.95 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint H7_AMD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_AMD | 0.969 [0.89, 1.06] | 0.482 |
| Birth year | 0.995 [0.99, 1.0] | 0.229 |
During the follow-up period (1.1.1998 — 31.12.2019), 24250 out of 58251 females with H7_AMD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_AMD | 0.995 [0.9, 1.1] | 0.929 |
| Birth year | 0.987 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 14459 out of 32798 males with H7_AMD died.
Mortality risk
Mortality risk for people of age
years, who have H7_AMD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.092% | 0.147% |
| 5 | 0.516% | 1.124% |
| 10 | 1.428% | 2.915% |
| 15 | 2.619% | 5.382% |
| 20 | 4.515% | 9.257% |
Relationships between endpoints
↥Index endpoint: H7_AMD – Age-related macular degeneration (whether dry or wet)
GWS hits: 25
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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