No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
136 |
4. Check minimum number of eventsNone |
136 |
5. Include endpointsNone |
136 |
6. Filter based on genotype QC (FinnGen only) |
130 |
Control definitions (FinnGen only)
Control exclude
M13_SOFTTISSUE
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M72
Similar endpoints
↥List of similar endpoints to
Necrotizing fasciitis
based on the number of shared cases.
Similar with more cases:
- Fibroblastic disorders
- Soft tissue disorders
- Diseases of the musculoskeletal system and connective tissue
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 969 | 395 | 574 |
| Only index persons | 953 | 390 | 563 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.02 |
| Only index persons | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | |||
| Whole population | - | 66.29 | 56.91 |
| Only index persons | 60.76 | 66.30 | 56.93 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 130 | 48 | 82 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.04 |
| Median age at first event (years) | 63.84 | 68.83 | 60.92 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint M13_NECROFASC and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_NECROFASC | 4.252 [2.17, 8.33] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.118 |
During the follow-up period (1.1.1998 — 31.12.2019), 69 out of 352 males with M13_NECROFASC died.
Mortality risk
Mortality risk for people of age
years, who have M13_NECROFASC.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.782% |
| 5 | No data | 4.842% |
| 10 | No data | 13.347% |
| 15 | No data | 24.441% |
| 20 | No data | 38.97% |
Relationships between endpoints
↥Index endpoint: M13_NECROFASC – Necrotizing fasciitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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