No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleonly males |
207946 |
2. Check conditionsNone |
207946 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
37948 |
4. Check minimum number of eventsNone |
37948 |
5. Include endpointsNone |
37948 |
6. Filter based on genotype QC (FinnGen only) |
36601 |
Control definitions (FinnGen only)
Control exclude
N14_MALEGEN
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N40-N51
Name in latin
Hyperplasia prostatae
Hyperplasia of prostate
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 306982 | - | 306982 |
| Only index persons | 237063 | - | 237063 |
| Unadjusted period prevalence (%) | |||
| Whole population | 8.58 | - | 8.58 |
| Only index persons | 9.05 | - | 9.05 |
| Median age at first event (years) | |||
| Whole population | - | - | 69.45 |
| Only index persons | - | - | 68.69 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 36601 | - | 36601 |
| Unadjusted period prevalence (%) | 18.38 | - | 18.38 |
| Median age at first event (years) | 68.19 | - | 68.19 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_PROSTHYPERPLA and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_PROSTHYPERPLA | 1.144 [1.06, 1.23] | < 0.001 |
| Birth year | 0.986 [0.98, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 76532 out of 209249 males with N14_PROSTHYPERPLA died.
Mortality risk
Mortality risk for people of age
years, who have N14_PROSTHYPERPLA.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.175% |
| 5 | No data | 1.063% |
| 10 | No data | 2.672% |
| 15 | No data | 4.985% |
| 20 | No data | 8.298% |
Relationships between endpoints
↥Index endpoint: N14_PROSTHYPERPLA – Hyperplasia of prostate
GWS hits: 54
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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