male reproductive organ cancer: A reproductive organ cancer that is manifested in the male genital system. This includes organs such as the penis and scrotum.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleonly males |
207946 |
2. Check conditionsNone |
207946 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
53256 |
4. Check minimum number of eventsNone |
53256 |
5. Include endpoints |
60063 |
6. Filter based on genotype QC (FinnGen only) |
57815 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Diseases of male genital organs
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 598067 | - | 598067 |
| Only index persons | 494738 | - | 494738 |
| Unadjusted period prevalence (%) | |||
| Whole population | 16.71 | - | 16.71 |
| Only index persons | 18.89 | - | 18.89 |
| Median age at first event (years) | |||
| Whole population | - | - | 58.73 |
| Only index persons | - | - | 55.94 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 57815 | - | 57815 |
| Unadjusted period prevalence (%) | 29.04 | - | 29.04 |
| Median age at first event (years) | 62.77 | - | 62.77 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_MALEGEN and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_MALEGEN | 1.143 [1.06, 1.23] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 88287 out of 382160 males with N14_MALEGEN died.
Mortality risk
Mortality risk for people of age
years, who have N14_MALEGEN.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.188% |
| 5 | No data | 1.13% |
| 10 | No data | 2.876% |
| 15 | No data | 5.224% |
| 20 | No data | 8.978% |
Relationships between endpoints
↥Index endpoint: N14_MALEGEN – Diseases of male genital organs
GWS hits: 18
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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