proctitis: An inflammatory process affecting the anus. It is usually caused by sexually transmitted infectious agents and/or inflammatory bowel disease.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
2240 |
4. Check minimum number of eventsNone |
2240 |
5. Include endpointsNone |
2240 |
6. Filter based on genotype QC (FinnGen only) |
2158 |
Control definitions (FinnGen only)
Control exclude
K11_ENERCOLNONINF
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K51
Name in latin
Proctitis ulcerosa [chronica]
Similar endpoints
↥List of similar endpoints to
Ulcerative proctitis
based on the number of shared cases.
Similar with more cases:
- Ulcerative colitis
- Inflammatory bowel disease
- Noninfective enteritis and colitis
- Autoimmune diseases related-to ILD
- Autoimmune diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13877 | 7303 | 6509 |
| Only index persons | 13418 | 7120 | 6298 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.20 | 0.21 | 0.18 |
| Only index persons | 0.25 | 0.26 | 0.24 |
| Median age at first event (years) | |||
| Whole population | 42.59 | 40.72 | 44.56 |
| Only index persons | 42.09 | 40.47 | 43.93 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2158 | 1227 | 931 |
| Unadjusted period prevalence (%) | 0.48 | 0.48 | 0.47 |
| Median age at first event (years) | 43.82 | 39.90 | 48.99 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint ULCERPROCT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ULCERPROCT | 1.073 [0.94, 1.23] | 0.305 |
| Birth year | 0.992 [0.98, 1.0] | 0.067 |
During the follow-up period (1.1.1998 — 31.12.2019), 443 out of 6386 females with ULCERPROCT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ULCERPROCT | 1.054 [0.94, 1.18] | 0.354 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 674 out of 5681 males with ULCERPROCT died.
Mortality risk
Mortality risk for people of age
years, who have ULCERPROCT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.095% | 0.217% |
| 5 | 0.556% | 1.228% |
| 10 | 1.432% | 3.08% |
| 15 | 2.668% | 5.909% |
| 20 | 4.512% | 9.884% |
Relationships between endpoints
↥Index endpoint: ULCERPROCT – Ulcerative proctitis
GWS hits: 7
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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