ulcerative proctosigmoiditis: Inflammation of the rectum and the distal portion of the colon.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
3181 |
4. Check minimum number of eventsNone |
3181 |
5. Include endpointsNone |
3181 |
6. Filter based on genotype QC (FinnGen only) |
3088 |
Control definitions (FinnGen only)
Control exclude
K11_ENERCOLNONINF
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K51
Name in latin
Rectosigmoiditis ulcerosa [chronica]
Similar endpoints
↥List of similar endpoints to
Ulcerative rectosigmoiditis
based on the number of shared cases.
Similar with more cases:
- Ulcerative colitis
- Inflammatory bowel disease
- Noninfective enteritis and colitis
- Autoimmune diseases related-to ILD
- Autoimmune diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 19206 | 8881 | 10235 |
| Only index persons | 18415 | 8651 | 9764 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.27 | 0.25 | 0.29 |
| Only index persons | 0.35 | 0.32 | 0.37 |
| Median age at first event (years) | |||
| Whole population | 44.63 | 42.34 | 46.50 |
| Only index persons | 43.93 | 41.94 | 45.70 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3088 | 1591 | 1497 |
| Unadjusted period prevalence (%) | 0.69 | 0.62 | 0.75 |
| Median age at first event (years) | 45.28 | 41.42 | 49.38 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint ULCERRECT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ULCERRECT | 1.163 [1.04, 1.3] | 0.008 |
| Birth year | 0.996 [0.99, 1.0] | 0.309 |
During the follow-up period (1.1.1998 — 31.12.2019), 677 out of 8056 females with ULCERRECT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ULCERRECT | 1.093 [1.0, 1.2] | 0.061 |
| Birth year | 0.983 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 1254 out of 9221 males with ULCERRECT died.
Mortality risk
Mortality risk for people of age
years, who have ULCERRECT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.07% | 0.233% |
| 5 | 0.59% | 1.167% |
| 10 | 1.628% | 2.921% |
| 15 | 3.162% | 5.473% |
| 20 | 5.425% | 8.891% |
Relationships between endpoints
↥Index endpoint: ULCERRECT – Ulcerative rectosigmoiditis
GWS hits: 16
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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